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These medications work by mimicking the action of the naturally occurring GLP-1 hormone, which stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety
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Conversely, discontinuation rates were increased to 28.1% (95% CI 27.7, 28.4) at 1 year and 43.6% (95% CI 43.2, 44.0) at 3 years when using a grace period of 60 days (ESM Table 4)
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