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The trace amount delivered through the skin from a peptide serum or balm is orders of magnitude below any threshold for systemic concern

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Greene and Wuts, Protective Groups in Organic Synthesis, John Wiley & Sons, 1999

ThermiSmooth is FDA-cleared for safety and efficacy in creating targeted injury and hemeostasis at precise points in the deep skin layers, a technique known to encourage the bodys immune response through the building of new collagen

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DSIP also has GABAergic activity but appears to modulate sleep architecture rather than simply sedating