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Across diabetes and obesity, there are ~20 novel GLP-1 agonists and multi-agonists in Phase 2/3 development (see image 2) , with a host more in earlier stages

SGLT-2 inhibitors also modestly lower blood pressure (comparable to the introduction of a thiazide diuretic), reduce albuminuria and induce modest weight loss

2022;10:tkac022

By age 60, those levels fall to roughly 80 ng/mL a decline that closely tracks the slowing of wound healing, skin thinning, and reduced regenerative capacity observed with aging