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Mitochondrial ROS are increased under hypoxia, ischemia/reperfusion injury, chemical stress, drug treatment, and under many pathophysiological conditions (Srinivasan and Avadhani, 2012)

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Toda et al., "Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues," Diabetes, vol