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Once central sensitization develops, even removing the original trigger may not immediately resolve the pain, because the amplification occurs in the central nervous system rather than at the periphery

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This is why long-term, uninterrupted therapy is recommended rather than stopping and restarting

Venous whole blood samples from patients were collected into 10 ml K2EDTA Vacutainers, centrifuged at 1000g for 10 min at +4C to collect 1,8 ml of plasma

The vial alone cannot be used as is

Like most medications, GLP 1s only work while you are taking them