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La inyeccin repetida en el mismo lugar puede causar lipohipertrofia (acumulacin de tejido graso) o lipoatrofia (prdida de tejido graso), condiciones que pueden afectar la absorcin del medicamento y causar irregularidades visibles en la piel

The effect varies by medication, dose, and whether the drug is used for diabetes or obesity, but the overall pattern is clear

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Improved metabolic flexibility Obesity and type 2 diabetes are commonly associated with impaired metabolic flexibility, meaning the body has difficulty switching efficiently between glucose and fat oxidation

Gut microbiome changes This is a newer area of research, but evidence is emerging that GLP-1 agonists alter the gut microbiome