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The diagnosis is established by: Low activity of gamma-glutamylcysteine synthetase in red blood cells, leukocytes and/or cultured skin fibroblasts

Additionally, only modest effects on airspace enlargement occur in mice after 6 months of CS exposure [24]

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Higher Dosages : In some treatment protocols, larger doses of B12 may be required, ranging from 1 ml to 3 ml

Wennberg A, Hyltander A, Sjoberg A, Arfvidsson B, Sandstrom R, Wickstrom I, Lundholm K: Prevalence of carnitine depletion in critically ill patients with undernutrition