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For some individuals, the convenience of nasal sprays improves adherence enough to make them the more practical long-term choice, even if bioavailability is lower than injectable forms

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In a 2025 review, after 1,200 mg intravenously twice a week for six weeks, 37.5% of participants reported lighter skin compared with 18.7% in the placebo group, and the effect faded after about six months

Glutathione S -transferase activities in mock- and GSTP1 -transfected HepG2 cells were in a similar range as reported previously in mock- (and GSTP1 -)transfected HepG2 cells ( GSTP1 -transfected cells unambiguously demonstrated the over-expression of functional GSTP1

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