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The main assumptions for MR were as follows: (1) the genetic predictors from genome-wide association studies (GWAS) served as instrumental variables (IVs) that are strongly associated with the exposure phenotypes

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References Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global Cancer Statistics 2020, GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

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