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These findings suggest bone-supportive effects mediated through GH/IGF-1 but do not establish clinical efficacy for osteoporosis prevention
In addition, catabolic genes Atrogin-1 and MuRF-1 were also not changed by the supplementation (data not shown)
First, phase II clinical trials evaluating MOTS-c in type 2 diabetes and sarcopenia are in development, and their results will provide the first randomized controlled evidence in humans to define therapeutic doses with statistical rigor
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TB-500, however, is generally ineffective orally
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