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The initiation of an SGLT2 inhibitor or a GLP-1 receptor agonist compared with a DPP-IV inhibitor was associated with lower CV events and death without increasing the overall incidence rate of severe safety outcomes, regardless of frailty status, Elisabetta Patorno, MD, DrPH , associate professor of medicine at Harvard Medical School and associate epidemiologist in the division of pharmacoepidemiology and pharmacoeconomics at Brigham and Womens Hospital, and colleagues wrote

However, as genotyping is not currently routinely available and serum vitamin B 12 measurement is cheap, our results reinforce the causal association of metformin treatment with vitamin B 12 deficiency and guideline recommendations for routine screening for vitamin B 12 deficiency in people treated with metformin

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Sci Rep 15(1):29387 Wang J, Zhou JJ, Robertson GR, Lee VW (2018) Vitamin D in vascular calcification: a double-edged sword

Also this was the guidance that management had given in Fy26 and here is the proof point of what they have delivered