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Once the B12 is in the muscle, it moves into the bloodstream over the following hours

The riskbenefit assessment for wellness or anti-aging interventions may differ substantially from that applied to disease-specific therapeutic indications, given the differing clinical objectives and risk tolerances

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In young mice, it suppressed the release of pro-inflammatory cytokines from macrophages, indicating a potential role in tempering an overactive immune response during youth [44]

So, at least its positive with that

doi: 10.1016/j.nicl.2023.103503