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Consistent with these findings, physiological measurements demonstrated that melatonin continued to improve airway function in the presence of Luzindole ( Figures 2O, P ), suggesting that receptor-independent mechanisms may contribute to melatonins protective effects in allergic airways disease
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The vasoprotective effect of SEM also corresponds to a previous study where SEM decreased vascular leakage in a mouse model of diabetic retinopathy [14]
BakshiSPaswanVKYadavSPBhinchharBKKharkwalSRoseHet al
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Access this article Similar content being viewed by others Abbreviations AAPH: Hydrochloride 2,2-azobis-2-amidinopropane AIDS: Acquired immunodeficiency syndrome ARE: Antioxidant response element CAT: Catalase Cu/Zn-SOD: Copper/zinc-superoxide dismutase DIVEMA: Divinyl ether and maleic anhydride DNA: Deoxyribonucleic acid EC-SOD: Extracellular-superoxide dismutase Fe-SOD: Iron-superoxide dismutase FIV: Feline immunodeficiency virus GPx: Glutathione peroxidase H 2 O 2 : Hydrogen peroxide HIV: Human immunodeficiency virus HO: Hydroxyl radical Mn-SOD: Manganese-superoxide dismutase Nrf2: Transcription factor nuclear-factor-E2-related factor O 2 - : Superoxide anion radical PEG: Pegylated PMA: Phorbol 12-myristate 13-acetate ROS: Reactive oxygen species SOD: Superoxide dismutase REFERENCES Davies KJA
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