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Moreover, the gr mutant grew lowest with a longer growth delay, while the gr overexpression strain grew highest with a shorter growth delay under the same concentration of zinc ions (Figure 8)

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Squalene accumulation in the host epithelial cell reduces ROS and enhances Cryptosporidium growth To rule out any off-target effects of NB-598 treatment, we created an SQLE -knockout ( SQLE -KO) HCT-8 cell line by Cas9-directed disruption of its genetic locus (Fig S3A, Fig S3B)

Reduced cellular protection, impaired detoxification, increased inflammation, and accelerated biological aging

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