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After 46 weeks of treatment, the results were particularly notable at higher dosages: Up to 40% of participants receiving the highest two doses achieved weight loss of 20% or more (compared to 0% with placebo)

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This is a tirzepatide-specific contraindication based on findings in rodent studies and is unrelated to bupropion

These medications work by mimicking the action of naturally occurring GLP-1, a hormone released from the gut after eating

Based on part 1 of the ESSENCE trial, Novo Nordisk has also filed for regulatory approval in the EU in February 2025, with a subsequent filing in Japan in May 2025

Some bruising, especially in softer or thinner-skinned areas