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Hsieh and colleagues (J Mol Med, 2017) reported that BPC 157 upregulated VEGFR2 expression and promoted receptor internalisation and downstream signalling in human umbilical vein endothelial cells, with increased tube formation in vitro and greater vessel density in a rodent hindlimb ischaemia model
However, the short elimination half-life of BPC-157 means even split dosing doesnt maintain truly constant levels
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Nat Rev Endocrinol 14(7):390403
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Mix the microparticles with the cell lysates and incubate them with continuous rotation for a sufficient time
