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For molecules excluded from oral development, this review has surveyed realistic alternatives that deserve systematic consideration: pulmonary delivery for rapid-onset needs, nasal delivery for rescue applications, buccal/sublingual delivery for potent peptides accommodating variability, and most importantly, long-acting injectables, depots, implants, and pumps that often outperform oral approaches on pharmacokinetic predictability and total cost

Oral delivery is the most effective for treating gastrointestinal issues

Therefore, therapy primarily focuses on providing patients with supportive care to manage their symptoms using dietary supplements [9]

Its been 10 years

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