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This is not a placebo effect on sleep

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Accordingly, the functional impact of NAD metabolism is determined not only by absolute pool size but also by turnover flux, compartmental exchange, and redox coupling across tissues

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Factors like activity level, diet quality, consistency with injections, and metabolic health all influence outcomes

[25] The magnitude and direction of phase shifts induced by exogenous melatonin depend on several factors, including the dose, timing of administration relative to the individuals endogenous circadian phase, and the patients sensitivity to melatonin