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Testing MTHFR and other relevant genetic markers can identify these individuals, though routine genetic testing for b12 supplementation decisions remains controversial

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Haematological symptoms often appear first

Exclusion criteria included (a) clinical studies that had menopause hormone therapy as a treatment, (b) case reports, (c) in vitro studies or (d) animal studies, and (e) duplicate articles or off-topic articles

(78) found that a three-month co-administration of Bifidobacterium lactis Probio-M8 with calcium and calcitriol improved bone metabolism in patients, as evidenced by decreased levels of bone turnover markers such as alkaline phosphatase (ALP) and osteocalcin (OC)