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Chlorogenic acid, a polyphenol, has demonstrated multiple mechanisms through which it exerts antidiabetic activity, including inhibition of alpha-glucosidase and the glucose-elevating liver enzyme glucose-6-phosphatase, oxidative stress modulation, insulin sensitization, and AMPK activation (Bassoli 2008
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Bernier FP, Snyder FF, McLeod DR: Deficiency of 5-oxoprolinase in an 8-year-old with developmental delay
Obstetric Gynecol Surv 50:497-498, 1995
Kono K et al