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3 RGN-259 Phase 3 Trial in Neurotrophic Keratopathy Sosne et al., International Journal of Molecular Sciences (2022) This Phase 3 randomized, placebo-controlled, double-masked clinical trial evaluated topical 0.1% RGN-259 (full-length recombinant T4 ophthalmic solution) in patients with neurotrophic keratopathy

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If there are signs of NAD+ deficiency, such as in pellagra, which manifests as dermatitis, dementia, or diarrhea, supplemental IV NAD therapy may be warranted

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