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These include that GSH depletion does not inhibit GPx4 activity, mitochondrial superoxide is the precursor of the actual toxin peroxynitrite, iron is an important catalyst for protein nitration, and LPO is quantitatively not a relevant event

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[1] In clinical studies, patients receiving clozapine plus adjunctive glycine experienced reduced antipsychotic benefit-likely owing to altered NMDA-receptor signaling

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