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Mass spectrometry analysis reveals that CHCHD2 interacts with MICS1 (Meng et al., 2017), which is involved in cristae organization and cyt c stabilization, thereby prohibiting cells from apoptosis (Oka et al., 2008)
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Similar clinical symptoms are found in individuals with hereditary IF deficiency (also called congenital pernicious anemia) in whom the lack of IF results in the defective absorption of vitamin B 12
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