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The kynurenine pathway in Alzheimers disease: a meta-analysis of central and peripheral levels

Methylcobalamin is commonly available in oral tablets or sublingual forms

Dysregulation of KEAP1-NRF2 activity has been extensively demonstrated in cellular and animal models of ALS and in postmortem ALS motor cortex and spinal cord samples, so dysregulation of the NRF2/ARE antioxidant and cytoprotective pathway could be a possible mechanism underlying the progressive neurodegeneration in ALS and severity of the disease

Statistical analysis The data were analyzed as the means SEMs, and all the data are expressed as the means standard deviation