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H2: Typical Cell Models The divergence in model systems reflects the divergence in pathways

Cytosolic ALDH1L1 mainly regulates reduced folate pools and purine biosynthesis, while mitochondrial ALDH1L2 produces NADPH in response to oxidative stress

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Specifically, the use of gas chromatography-mass spectrometry (GC-MS), allows highly efficient and sensitive analyses with widely available libraries for metabolite identification

The plate was loaded into BMGs Fluostar Optima multimode plate reader (NY, USA), controlled by native software (version 2.10 R2)

Biological age and telomere lengths were measured at baseline, 9 months, and 16 months using TruAge