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10.1136/bjophthalmol-2021-319232 62 SunY.ZhangY.ShiF.LiY.WangC.YuF.et al (2025)
Responsible Research Practices To approach IGF-1 LR3 research safely: Start with baseline assessment: Measure fasting glucose, lipid profile, and basic metabolic panel before initiating research Monitor blood glucose regularly: Particularly in the first 1-2 weeks and with any dose adjustment
How to implement: Dosing: General health : 5-10 grams daily Glutathione optimization : 10-15 grams daily (divided doses) Aging/longevity : 15 grams daily (research shows benefits for lifespan) Forms: Glycine powder : Tasteless, mixes in water/coffee/smoothies Collagen peptides : 10-20 grams daily (33% glycine by weight = ~3-7g glycine) Bone broth : Rich source (8-10g glycine per cup) Timing: With meals (supports protein synthesis) Before bed : 3-5 grams (improves sleep quality via NMDA receptor modulation) Synergy with NAC: Combine NAC (600 mg 2 daily) + Glycine (5g 2 daily) for maximum glutathione boost Research shows this combination increases glutathione more than either alone [11] Evidence: A study in older adults found that glycine supplementation (15g daily) increased glutathione by 25% and reduced oxidative stress markers by 30% within 2 weeks [12]
Week-by-week titration schedules built around the 10 mg supply
Rodent models have proportionally larger olfactory epithelia relative to body size
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