new glp 1 gip drug In a recent study published in Nature, researchers discovered a five-target called lanifibranor that outperforms GLP-1/GIP therapy in obese diabetic mice. This single-molecule compound activates incretin receptor-expressing cells and PPARα/γ/δ GLP-1/GIP | Drip Lounge |

Hata A, Doi Y, Ninomiya T, Mukai N, Hirakawa Y, Hata J,

Xanthine-oxidase inhibitors and statins in chronic heart failure: effects on vascular and functional parameters

doi: 10.3389/fimmu.2022.978800 58 BoatengATAbaidoo-MylesABonneyEYKyeiGB

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demonstrated that although the combination therapy (metformin 1000 mg BID + liraglutide 1.2 mg/day) resulted in a greater weight loss than liraglutide alone, both groups showed an increase in SHBG and a decrease in free testosterone, with no differences between the two treatment arms, thus suggesting that the effect on the biochemical hyperandrogenism of liraglutide may be partially independent of the extent of weight loss [60]