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Landmark analysis To address immortal time bias, we performed a landmark analysis by refining the cohort selection period, adjusting it from the initial 3 months post-transplant to specific time points within 2, 6, 9, and 12 months post-transplant [45]
Reduced frequency may also reduce side effects for some people
How It Works When a person takes Ozempic, the drug interacts with receptors for a naturally occurring hormone called glucagon-like peptide-1 (GLP-1)
In SELECT, 16.6% of patients on semaglutide stopped the drug because of adverse events, against 8.2% on placebo, mostly gastrointestinal. In the meta-analysis, GI disorders were 63% more common with GLP-1 receptor agonists, gallbladder disorders 26% more common. Most patients tolerate them well
Nonetheless, rigorous clinical trials are needed to establish the safety, efficacy, and optimal protocols for these combination regimens in MASLD patients (5658)
Lobene, A
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