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Inhibition of Glutamate cysteine ligase depletes neuronal glutathione, elevates glutamate and increases excitatory neurotransmission Glutamate cysteine ligase (GCL) is the rate limiting step for glutathione synthesis, and utilizes glutamate as a substrate
Leonardi C, Matheson R, Zachariae C, Cameron G, Li L, Edson-Heredia E,
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