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Adequate amino acid availability is required to sustain protein synthesis, antioxidant synthesis, and metabolic homeostasis, and reductions in amino acid supply may therefore influence the capacity of redox-buffering systems that maintain oxidative stability because glutathione synthesis depends on cysteine and related amino acid precursors [78, 79]

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In liver disease, semaglutide received FDA accelerated approval in August 2025 for metabolic dysfunction-associated steatohepatitis in adults with moderate-to-advanced fibrosis