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This framework illustrates that real cost is determined by multiple performance factors rather than price alone

47,48 Peptides possessing greater molecular dimensions and increased conformational flexibility relative to small molecule drugs may offer a solution to the challenge

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For instance, conflicting findings on PPR-warfarin interactions highlight this complexity: some studies report PPR-mediated inhibition of warfarin metabolism, increasing plasma concentrations and anticoagulant effects (95), while others suggest diminished efficacy (91)