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The relationship between body weight and optimal dosing has not been established through controlled trials
When picking a B12 formulation, its key to think about the patients specific needs and any possible interactions with other drugs
They were probably related
Baseline and interval laboratory monitoring should include: fasting glucose and HbA1c (tirzepatide can cause hypoglycemia in non-diabetic subjects if caloric intake drops too low), lipase and amylase (pancreatitis risk with GLP-1 agonists), liver function tests (AST, ALT, bilirubin), and thyroid panel (TSH, free T3, free T4)
Discuss the risks and benefits with your doctor