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CB-839 is the most advanced GLS1 inhibitor currently in clinical practice and has been shown to effectively inhibit tumor proliferation ( L-asparaginase can deplete plasma Gln and is widely utilized as an adjuvant therapy in lymphoma ( In vitro experiments on lung cancer cells revealed that L-asparaginase treatment significantly induced autophagy activation in A549 cells, leading to their apoptosis ( 5 Discussion Metabolic reprogramming is essential for the advancement of tumors and has become a central topic in cancer research lately ( While substantial progress has been accomplished in the study of tumor Gln metabolism in recent years, several key issues remain to be addressed (1)

Conversely, antioxidant systems effectively scavenge HO, thereby reducing DNA damage, PARP-1 activation, and further parthanatos inhibition

6 The peptide has demonstrated efficacy in healing transected muscles and restoring myotendinous junctions in animal models

In 1979, Creutzfeld explained the phenomenon, stating that the digestive tract secretes hormones that amplify the glucose signal to induce insulin secretion [16]

doi: 10.1042/CS20190946 45

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