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The third mechanism is perhaps the most intriguing from an aging perspective

There is damage to the substantia nigra (pars compacta) and a decrease in dopamine production

AOD-9604 is the more-studied stabilized version Compound Human Growth Hormone (somatropin) Class Full-length recombinant hGH FDA Status FDA-approved for specific indications (GH deficiency, certain growth disorders, AIDS wasting) Evidence Strength Strong human evidence for approved indications

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Model performance of efficacy was further assessed by applying the model derived from our self-report data in a sample of 642 people who had provided HealthKit EHR data but had not completed the GLP1 survey, and hence were not used in the construction of the model