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Moreover, Genistein, by reduction of pro-inflammatory mediators (IL-6, tumor necrosis factor- (TNF-) and C-reactive protein (CRP)) in serum and intestine in alloxan-induced diabetic rats, reduces the damage of L-cells and leads to an increase in the expression and secretion of GLP-1[191]

Obesity induces PD-1 on macrophages to suppress anti-tumour immunity

5B) effects on murine macrophages RAW264.7 upon antigen stimulation, TNF- and phosphorylated inhibitor of B (IB) decreased and histone deacetylase 2 increased [108]

Activation of PPAR improves insulin sensitivity in the adipose tissue, liver and skeletal muscle 10,11,23

The liver benefits are particularly noteworthy

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