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Antidepressant-like effects of glucagon-like peptide-2 in mice occur via monoamine pathways
Potential mechanisms by which peptide exposure could influence surgical outcomes include dysregulated angiogenesis contributing to hematoma formation, altered inflammatory signaling affecting early wound healing, and perturbations in collagen organization that may influence soft-tissue integrity during the critical postoperative period
However, due to the widespread presence of anti-PEG antibodies and PEG complement activation in vivo, peglosanatide is limited to the suitable population
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59 Recently, the SURMOUNT-5 trial demonstrated that tirzepatide was superior to semaglutide in obese patients without diabetes with respect to reductions in body weight and waist circumference at week 72
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