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Rumack BH, Bateman DN

its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin

Once received, proper refrigerator storage maintains product quality throughout the treatment period

van den Bos MAJ, Geevasinga N, Higashihara M, Menon P, Vucic S

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doi: 10.1016/j.ultrasmedbio.2018.11.010 163 TofarisG