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The Endocrine Society's 2023 clinical practice guideline for pharmacological management of obesity recommends that clinicians "prioritize medications with the greatest efficacy for weight reduction when obesity is the primary treatment target" [13]

This is the minimum timeframe established by clinical trial protocols for safe dose escalation

But I do think it is something that we should be looking at because there are people who have insulin dysregulation even though they're not obese and they're not overweight

Draw air into the syringe equal to the diluent amount on your clinic label

Thus, all adjuvant glucose-lowering therapies in type 1 diabetes are used off-label and contrary to local and national guidance [16]

For full clinical data, see our GLP-1 weight loss guide