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10.2196/28953 J Med Internet Res
They have become super popular because they are great at helping manage weight, but thats not all
Combined treatment with diuretics and DPP-4i may amplify the effects of diuretics upon the reduction of BP and decreasing cardiac load
In fact, logically, lower doses are likely to mean fewer side-effects
More serious but rare safety considerations include pancreatitis (discontinue if suspected), gallbladder disease, potential thyroid C-cell tumors (based on rodent studies), risk of hypoglycemia when used with insulin or sulfonylureas, and potential for acute kidney injury with severe dehydration
Least-squares mean percentage changes in body weight at week 48 were 8.7% (1 mg), 17.1% (4 mg), 22.8% (8 mg), and 24.2% (12 mg), compared with 2.1% in the placebo arm
