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These overlapping mechanisms make digestive adjustment a predictable but manageable part of early therapynot a sign of treatment failure

Patients with metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) and insulin resistance may experience improvements in hepatic steatosis and liver enzyme elevations, though this represents an off-label use with evolving evidence

Some people lost weight quickly in the trials

On the heart and circulation, the Phase 2 data show consistent reductions in resting blood pressure of approximately 5 to 8 mmHg at the higher doses, alongside large improvements in the cholesterol pattern most associated with heart disease

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45 Currently, the strategy of multiple receptor stimulation is actively expanding indications in metabolic disorders, particularly in MASLD, and some medications have reported more potent therapeutic efficacy compared to single GLP-1RA