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However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig

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Preliminary data on cows reared in polluted areas show increased expression of e-GST that parallels the results found for humans

Raffa M, Barhoumi S, Atig F, Fendri C, Kerkeni A, Mechri A

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6,7,20 There is an intimate connection between abnormal GST expression and multidrug resistance, unequivocally implicating GST, a member of the GST family in tumor-drug resistance