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Suspected adverse drug reactions, including possible metformin-associated B12 deficiency, can be reported via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)

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In general, dose selection for an elderly patient should be cautious, usually starting at a low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or drug therapy

Granite suggests applying the ingredient at night when your skin is naturally in repair mode

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