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PHHs have been widely used in clinical trials which easily lose functions during cell isolation, culture, and cryopreservation (Sun et al., 2023)
In the pivotal STEP 1 clinical trial, participants who received weekly semaglutide injections lost an average of 14.9% of their body weight over 68 weeks , compared with 2.4% in the placebo group (study in the New England Journal of Medicine )
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Oncogene 30 , 40754086 (2011)
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