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These observations were reaffirmed by Zare and co-workers who used the same doses (0.3 and 0.6 mg/mL) of LC supplementation during in vitro maturation of immature BCB+ (Brilliant Cresyl Blue positive) oocytes

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Once circulating in the bloodstream, these free-form amino acids are readily and efficiently taken up by cells across the entire body, including the highly guarded brain, liver, and skeletal muscle tissue

In addition to inducing HF by promoting atherosclerotic progression, elevated plasma TMAO levels may accelerate myocardial hypertrophy, exacerbate mitochondrial dysfunction, and induce transverse-tubule (T-tubule) remodeling in cardiomyocytes (93)