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DSIP is thought to increase production of GABA (20)a neurotransmitter that slows brain activity, promotes relaxation, and increases time spent in deep sleep
1998 Mar 17;95(6):3071-6
Mechanistically, DAMPs interact with toll-like receptors (TLRs) and purinergic receptors on Kupffer cells, resulting in the secretion of pro-inflammatory mediators such as IL-6, IL-18, IFN-, TNF-, and Fas ligands, which further promote macrophage proliferation [54]
Zavadakova P, Fowler B, Zeman J, Suormala T, Pristoupilova K, Kozich V, et al
While smoking cessation may initially be associated with weight gain, potentially influencing MASLD development, the overall benefits far outweigh this risk, provided patients are monitored by a multidisciplinary team including dieticians [143, 144]
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