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These trials collectively demonstrated participants receiving semaglutide experienced consistent reductions in body weight, accompanied by improvements in waist circumference and cardiometabolic risk factors
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In addition to stimulating GLP-1 receptors, it also activates glucose-dependent insulinotropic polypeptide (GIP) receptors, which are involved in both insulin signaling and lipid metabolism (Nauck & DAlessio)
A 2019 systematic review published in the National Library of Medicine identified improvements in skin brightness across several small trials while emphasising the need for larger controlled studies before definitive claims can be made
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