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these cells continue to proliferate at metformin concentrations that would normally suppress tumor cell growth ( In summary, metformin has demonstrated inhibitory effects on glioma through various mechanisms, including regulating cellular oxygen consumption, affecting mitochondrial respiration, inducing AMPK activation, and regulating oxidative stress, etc

They do have quite a few mixes, but I dont think they have that

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doi: 10.1016/j.it.2005.11.006 31 LiQWangBMuKZhangJ-A

found that oxidative stress changed the redox potential of the breast, leading to drastic changes in the DNA base lesions, which are conducive to oxidative conditions and breast cancer formation [64]