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In the same light, older people i.e., those of age 52 and above are also more vulnerable
Pancreas GLP-1 and GIP stimulate insulin secretion GLP-1 suppresses glucagon secretion during hyperglycemia GIP suppresses glucagon secretion during hyperglycemia and stimulates secretion during euglycemia and hypoglycemia Brain GLP-1 and GIP suppress hunger Stomach GLP-1 slows gastric emptying Fat tissue GIP increases fatty acid and glucose uptake by fat tissue [1,2,3] Tirzepatide Tirzepatide is a dual GLP-1 / GIP receptor agonist that mimics the actions of GLP-1 and GIP
For this reason, limiting alcohol intake is generally recommended
Who should avoid Tirzepatide: Tirzepatide (Mounjaro, Zepbound) carries similar restrictions and is contraindicated in: Individuals with a personal or family history of MTC Those with MEN 2, due to the same cancer-related concerns People who have experienced severe gastrointestinal issues, such as chronic pancreatitis or gastroparesis Patients with a known hypersensitivity to tirzepatide or any of its components As always, anyone considering these medications should talk with their healthcare provider about their personal health history and risk factors
doi: 10.3390/ijms21165911 89 IshiiAFurushoMDupreeJLBansalR
This is evident from studies where exenatide blunted the fMRI signal in brain areas such as the amygdala, insula, hippocampus, and frontal cortex in obese individuals but not in lean individuals [16, 17]
