[1] [2] Systemic symptoms such as fatigue and headache are also recognised, and these may contribute to a flu-like feeling, especially when combined with reduced caloric intake and the body's adjustment to weight loss
Younger patients who achieve substantial weight loss and demonstrate capacity for sustained dietary and exercise changes may be candidates for medication discontinuation with close monitoring
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However, approximately 10% of patients continue to experience mild burping throughout their treatment, though even this mild form rarely requires medication changes
For that reason, semaglutide has been used for more than 15 years to treat Type 2 diabetes
In adults with type 2 diabetes, treatment with tirzepatide 5 mg, 10 mg and 15 mg once weekly was associated with superior weight reduction from baseline compared with placebo, semaglutide 1 mg weekly, titrated insulin degludec, titrated insulin glargine and titrated insulin lispro as an add-on to insulin glargine