While the differences are not enormous, they are consistent across doses, and they become more meaningful at higher weight loss thresholds where muscle preservation becomes increasingly challenging
For example, in the STEP 1 trial extension, patients who stopped semaglutide after 68 weeks of treatment regained about two thirds of the weight they had lost within one year of discontinuation
GLP-1 combination incretins : dual or triple agonists (e.g., GIP/GLP-1
doi: 10.1007/s10571-017-0469-1 Summary Keywords sinomenine, cerebral ischemia, drug delivery, neuroinflammation, bonebrainaxis Citation Li X, Zhang X, Wang T, Li H, Li Y, Liu J and Bai Y (2025) Sinomenine in cerebral ischemia: mechanisms, delivery strategies, and the emerging multifunctional biomaterials of the bonebrain axis
They both contain silicones
GLP-1 receptor agonistsincluding semaglutide, liraglutide and dulaglutideare prescribed for type 2 diabetes and obesity management, but costs vary dramatically depending on how you access them